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Le DSIP (Delta Sleep-Inducing Peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) is a nonapeptide isolated in 1977 by Schoenenberger from rabbit venous blood subjected to electrical stimulation of the thalamus

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We found that only the combination containing Cu 2+ and Qu including CQ and ZCQ could effectively increase the expression of PDGF and c-Myc, and decrease the expression of TGF-1, and ZCQ group revealed higher regulation activity than CQ group